RESEARCH & ARTICLES

Clinical Outcomes after Revision of Autologous Chondrocyte Implantation to Osteochondral Allograft Transplantation for Large Chondral Defects: A Comparative Matched-Group Analysis

Purpose: This study examines the clinical outcomes of Osteochondral Allograft (OCA) transplantation after failed autologous chondrocyte implantation (ACI) for large chondral defects of the knee, compared to a matched cohort undergoing primary OCA cartilage repair.

Summary:

  • 13 patients who underwent revision OCA after failed ACI were compared to a matched cohort of patients undergoing OCA as a primary repair.
  • No significant differences in patient reported outcomes were observed between patients undergoing primary OCA or patients undergoing OCA after failed ACI.
  • Reoperation rates were also not significantly different between patients undergoing primary OCA or patients undergoing OCA after failed ACI.


JRF Ortho Take Away: This data highlights the versatility of OCAs in revising large chondral defects post failed ACI. Clinical outcomes of OCA revision following failed ACI are comparable to primary OCA repairs, underscoring their value for surgeons in cases of failed ACI.

Click Here for the Abstract

Authors: Gergo Merkely, Takahiro Ogura, Jakob Ackermann , Alexandre Barbieri Mestriner, and Andreas H. Gomoll.

Publication: Cartilage

Institution: Brigham and Women’s Hospital, Harvard Medical School, Boston and Hospital for Special Surgery, New York,